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Severe La Crosse encephalitis with significant neurologic sequelae.

H H Balkhy¹, J R Schreiber

¹Department of Pediatrics, Case Western Reserve University School of Medicine and Rainbow Babies and Children's Hospital, Cleveland, OH, USA.

The Pediatric Infectious Disease Journal

|January 22, 2000

Summary

La Crosse encephalitis, a mosquito-borne illness, can cause severe meningoencephalitis and lasting neurologic issues, challenging its reputation as a typically mild disease. This finding highlights the need for increased awareness and prompt medical attention for La Crosse virus infections.

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Area of Science:

Arbovirology
Neuroscience
Public Health

Background:

La Crosse encephalitis, caused by the La Crosse virus, is a significant mosquito-borne illness in the U.S.
The primary vector, Aedes triseriatus mosquitoes, transmits the virus through a cycle involving small mammals and specific egg-laying sites.
Typically, La Crosse encephalitis presents as a mild illness in children, with infrequent neurological complications.

Observation:

This report details six cases of severe La Crosse meningoencephalitis observed over a four-week period.
All affected patients required intensive care unit admission.
A high incidence of neurological sequelae was noted among these severe cases.

Findings:

The observed cases demonstrate that La Crosse encephalitis can manifest as a severe meningoencephalitis.

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Severe presentations are associated with a significant risk of long-term neurological deficits.

The typical mild course of the disease may not always apply.

Implications:

These findings challenge the perception of La Crosse encephalitis as a uniformly benign condition.
Increased vigilance and prompt diagnosis are crucial for managing severe cases.
Further research into factors influencing disease severity and long-term outcomes is warranted.