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Related Experiment Videos

Feline papillomas and papillomaviruses.

J P Sundberg1, M Van Ranst, R Montali

  • 1The Jackson Laboratory, Bar Harbor, ME 04609-1500, USA. jps@jax.org

Veterinary Pathology
|January 22, 2000
PubMed
Summary

This study identified eight novel papillomaviruses (PVs) infecting six feline species, causing proliferative skin and oral lesions. These findings highlight the diversity of PVs in cats and their potential for causing benign tumors.

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Area of Science:

  • Veterinary Virology
  • Dermatology
  • Oncology

Background:

  • Papillomaviruses (PVs) are known pathogens of stratified squamous epithelium, typically exhibiting high species and site specificity.
  • PV infections are rarely reported in Felidae, making their prevalence and characteristics in this family poorly understood.

Purpose of the Study:

  • To identify and characterize papillomaviruses in various feline species.
  • To investigate the clinical and histological features of PV-induced lesions in cats.
  • To determine the antigenic relatedness and genetic variability of feline PVs.

Main Methods:

  • Immunohistochemical screening using monoclonal antibodies against bovine papillomavirus L1 gene product to detect PV capsid antigens.
  • Histological examination of epidermal hyperplasia and proliferative lesions.

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  • Restriction endonuclease analysis of viral genomic DNA from recovered viral isolates.

    • Main Results:

    • Productive PV infections were identified in six cat species, manifesting as proliferative skin or mucous membrane lesions.
    • Monoclonal antibodies revealed conserved but differentially expressed capsid epitopes among cutaneous and oral PVs, suggesting distinct viral entities.
    • Lesions were locally extensive and multiple, histologically resembling benign tumors seen in immunosuppressed humans.
    • Genomic DNA analysis indicated variability among three recovered viral genomes.
    • At least eight distinct feline PVs were tentatively identified, infecting either the oral cavity or skin.

    Conclusions:

    • This study expands the known diversity of papillomaviruses by identifying at least eight novel feline PVs across six species.
    • Feline PVs exhibit species and site specificity, similar to PVs in other mammals.
    • The findings suggest that feline PVs can induce proliferative lesions with histological similarities to benign tumors in immunosuppressed humans.