Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cryptococcosis in AIDS.

P Imwidthaya¹, N Poungvarin

¹Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Postgraduate Medical Journal

|January 22, 2000

Summary

This study on cryptococcal meningitis in AIDS patients found that Cryptococcus neoformans isolates were sensitive to key antifungal agents, including amphotericin B and fluconazole. These findings are crucial for guiding treatment strategies in Thailand.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical outcome of treatment of metastatic non-small cell lung cancer in patients harboring uncommon EGFR mutation.

BMC cancer·2019

Same author

Alzheimer's disease dementia as the diagnosis best supported by the cerebrospinal fluid biomarkers: difference in cut-off levels from thai experience.

International journal of Alzheimer's disease·2012

Same author

Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity.

Diabetologia·2012

Same author

A double-blind, placebo-controlled, randomized, multicenter study to investigate CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES Study).

International journal of stroke : official journal of the International Stroke Society·2009

Same author

Neurological letter from ...Bangkok.

Practical neurology·2008

Same author

Galantamine for the treatment of BPSD in Thai patients with possible Alzheimer's disease with or without cerebrovascular disease.

American journal of Alzheimer's disease and other dementias·2008

Area of Science:

Infectious Diseases
Mycology
Clinical Medicine

Background:

Cryptococcal meningitis is a significant opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS).
Understanding the epidemiology and antifungal susceptibility patterns of Cryptococcus neoformans is vital for effective treatment.

Purpose of the Study:

To investigate the clinical characteristics, diagnostic methods, and antifungal susceptibility of Cryptococcus neoformans in patients with AIDS-related cryptococcal meningitis.
To determine the prevalence of different serotypes of Cryptococcus neoformans.

Main Methods:

Retrospective analysis of 87 patients diagnosed with cryptococcal meningitis and underlying AIDS.
Diagnosis confirmed by culture, India ink preparation, latex agglutination, and polymerase chain reaction (PCR).
Antifungal susceptibility testing performed for amphotericin B, flucytosine, fluconazole, and itraconazole.

Main Results:

The majority of patients (70 males, 17 females) were diagnosed with cryptococcal meningitis and AIDS.
Polymerase chain reaction (PCR) fingerprinting identified 99% of isolates as serotype A.
All isolates demonstrated sensitivity to the tested antifungal agents, with low minimum inhibitory concentrations (MICs).

Conclusions:

Cryptococcal meningitis in AIDS patients in Thailand is predominantly caused by serotype A of Cryptococcus neoformans.
The study confirms the in vitro sensitivity of these isolates to standard antifungal therapies, supporting their use in clinical management.

Related Experiment Videos