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[alpha-Neurotoxins and alpha-conotoxins--nicotinic cholinoreceptor blockers]
Iu N Utkin1, I E Kasheverov, V I Tsetlin
1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. utkin@ibch.siobc.ras.ru
Bioorganicheskaia Khimiia
|January 25, 2000
Abstract:
The review is devoted to the competitive blockers of different nicotinic acetylcholine receptors, alpha-neurotoxins from snake venoms, and alpha-conotoxins from marine snails of the Conidae family. The relationship between the structure and function of these toxins is discussed. Recent data on the mechanism of alpha-neurotoxin and alpha-conotoxin interaction with the nicotinic acetylcholine receptor are presented.