Related Experiment Video
Updated: Aug 27, 2026

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
Published on: March 5, 2017
Abstract:
There are two alternative hypotheses for the selective advantages of sex: (i) The "Fisher-Muller" model:sex facilitates evolutionary adaptation to chaning environments. (ii) The "Rachet" model: sex minimises the mutational load. The relative importance of these hypotheses is discussed with reference to (a) comparative data on sexual and asexual reproduction, (b) the timing of sex in species with asexual/sexual alternation, (c) the advantages of haploid/diploid alternation, (d) the disadvantage associated with the recombinational load. It is concluded that the Ratchet model may well be the major mechanism which maintains sex.
More Related Videos
Related Concept Videos
Mismatch Repair
In-vitro Mutagenesis (Gene Knockouts)
Viral Mutations
Genome Copying Errors
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Spontaneous and Induced Mutations

