Follow-up studies of cortisone teratogenicity in CD1 strain mice

The present study was done to evaluate the incidence of cortisone-induced cleft palate in the offspring of CD1 strain mice whose mothers had been injected with cortisone during their own pregnancy. The incidence of induced cleft palate was as high as the incidence of cortisone-induced cleft palate reported previously for the CD1 strain, indicating that the predisposition of CD1 mice to the teratogenic effects of cortisone is not altered significantly when the F2 generation is treated in utero with the same teratogenic agent.