Vaccination against infections by Chlamydia pneumoniae

Chlamydia pneumoniae is an intracellularly growing bacterium that causes respiratory infections and is strongly associated with atherosclerosis. Antibodies against C. pneumoniae are frequently encountered in the adult population, indicating past exposure to the micro-organism. Immunity to reinfection is, however, only partial and does not prevent development of sequelae. Infections caused by and associated with C. pneumoniae are a major cause of morbidity and mortality world wide. Development of a vaccine capable of protecting against infections due to C. pneumoniae and their sequelae would prevent up to 10% of community-acquired pneumonias in adults and add a new dimension to the prevention of atherosclerosis and coronary heart disease.