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Telomerase activity in thyroid malignancy.

C Y Lo1, K Y Lam, K T Chan

  • 1Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, China. cylo@hkucc.hku.hk

Thyroid : Official Journal of the American Thyroid Association
|January 26, 2000
PubMed
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Telomerase activity is infrequently found in papillary thyroid carcinoma, limiting its use as a tumor marker. Further research is needed to understand telomerase

Area of Science:

  • Oncology
  • Molecular Biology
  • Pathology

Background:

  • Telomerase activity is implicated in thyroid carcinoma development and pathogenesis.
  • The diagnostic and prognostic utility of telomerase as a tumor marker in thyroid cancer requires further investigation.

Purpose of the Study:

  • To determine the incidence of telomerase activity in various thyroid lesions, including papillary thyroid carcinoma.
  • To evaluate the potential of telomerase as a tumor marker for thyroid carcinoma.

Main Methods:

  • Thyroid tissue samples were collected from 1996-1998 and stored at -80°C.
  • Telomerase activity was assessed using the telomeric repeat amplification protocol (TRAP).
  • Histological examination of 67 benign and 59 malignant thyroid tissues was performed.

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Main Results:

  • Telomerase activity was detected in 29% of papillary thyroid carcinomas, 100% of thyroid lymphoma, and 50% of anaplastic carcinomas.
  • Activity was absent in normal thyroid tissue, follicular adenoma, nodular hyperplasia, follicular carcinoma, and medullary carcinoma.
  • Telomerase was present in 25% of adjacent lymphocytic thyroiditis specimens associated with papillary thyroid carcinoma.

Conclusions:

  • Telomerase activation is not a frequent event in papillary thyroid carcinoma.
  • The presence of telomerase activity in associated lymphocytic thyroiditis may confound its utility as a specific tumor marker for thyroid cancer.