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Graves' disease and recurrent ectopic thyroid tissue.

S Basaria1, D S Cooper

  • 1Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. sbasaria@welch.jhu.edu

Thyroid : Official Journal of the American Thyroid Association
|January 26, 2000
PubMed
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Ectopic thyroid tissue, often asymptomatic, can cause airway obstruction. This case highlights recurrence of mediastinal ectopic thyroid tissue, potentially triggered by thyroid-stimulating immunoglobulins in Graves' disease.

Area of Science:

  • Endocrinology
  • Surgical Pathology
  • Immunology

Background:

  • Ectopic thyroid tissue arises from aberrant migration during embryonic development, occurring in 7%-10% of individuals.
  • While often asymptomatic, ectopic thyroid tissue can lead to upper aerodigestive tract obstruction.
  • The thyroid gland's normal location is the pretracheal position.

Observation:

  • A patient presented with substernal chest pain due to ectopic mediastinal thyroid tissue, which was surgically removed.
  • The ectopic thyroid tissue recurred nine years post-surgery.
  • The recurrence coincided with the patient developing Graves' disease.

Findings:

  • The recurrence of ectopic mediastinal thyroid tissue is proposed to be influenced by thyroid-stimulating immunoglobulins (TSI).

Related Experiment Videos

  • This case suggests a potential link between autoimmune stimulation and ectopic thyroid tissue behavior.

    • Implications:

    • Understanding the role of TSI in ectopic thyroid tissue recurrence may inform future treatment strategies.
    • Further research into the immunopathogenesis of ectopic thyroid tissue is warranted.
    • This case underscores the importance of long-term monitoring for patients with ectopic thyroid tissue, especially those with autoimmune thyroid conditions.