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Melatonin reduces quinolinic acid-induced lipid peroxidation in rat brain homogenate
1Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa. chsd@giraffe.ru.ac.za
Metabolic Brain Disease
|January 26, 2000
Abstract:
The protective effects of melatonin against the neurotoxin, quinolinic acid, were investigated in rat brain homogenate using the thiobarbituric acid assay. Quinolinic acid increased lipid peroxidation in a dose dependent manner. When homogenate was cotreated with melatonin there was a significant decrease in lipid peroxidation. The results of the present report show that melatonin may play a protective role in the brain against the neurohormone quinolinic acid, which has been identified as a causative agent in Huntington's Disease.