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Bacterial colonization of functionalized polyurethanes.

R G Flemming1, C C Capelli, S L Cooper

  • 1Department of Chemical Engineering, University of Wisconsin, Madison 53706, USA.

Biomaterials
|January 26, 2000
PubMed
Summary
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New functionalized polyurethanes were tested for antibacterial properties against Staphylococcus aureus. Zwitterionic and quaternized amine polyurethanes demonstrated significant bactericidal effects, preventing bacterial colonization.

Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Microbiology

Background:

  • Polyurethanes are widely used in biomedical applications.
  • Bacterial colonization on medical implants poses a significant challenge.
  • Developing antimicrobial surfaces is crucial for preventing infections.

Purpose of the Study:

  • To develop and evaluate novel functionalized polyurethanes for their ability to inhibit bacterial growth.
  • To assess the antibacterial efficacy of zwitterionic and quaternized amine polyurethanes.
  • To investigate the influence of protein adsorption on the antimicrobial properties of these materials.

Main Methods:

  • A protocol was established to study bacterial growth on various functionalized polyurethanes, including Pellethane, sulfonated Pellethane, phosphonated Pellethane, quaternized amine polyurethanes, and a zwitterionic phosphonated polyurethane.

Related Experiment Videos

  • Bacterial inocula (Staphylococcus aureus) were applied, and growth was monitored over 24 hours.
  • Experiments were conducted with and without bovine serum albumin coating to simulate physiological conditions.

    • Main Results:

    • Pellethane, sulfonated Pellethane, and phosphonated Pellethane supported bacterial growth.
    • Zwitterionic phosphonated polyurethane and quaternized amine polyurethanes exhibited significant bactericidal activity, reducing bacterial populations.
    • Antimicrobial properties were retained even after coating with bovine serum albumin, with zwitterionic materials showing superior efficacy.

    Conclusions:

    • Functionalized polyurethanes, particularly zwitterionic and quaternized amine types, show promise as antimicrobial biomaterials.
    • The observed bactericidal activity of zwitterionic polyurethane may be linked to cadmium ion leaching.
    • Iodide-containing quaternized amine polyurethanes demonstrated enhanced antimicrobial performance compared to chloride-containing variants.