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Conjunctival lymphocytic infiltrates associated with Epstein-Barr virus
A S Feinberg1, C W Spraul, J T Holden
1Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Ophthalmology
|January 27, 2000
Summary
Epstein-Barr virus (EBV) can cause conjunctival lymphocytic infiltrates, ranging from reactive responses to clonal B cell populations. This study details two such cases, highlighting the spectrum of EBV-associated ocular conditions.
Area of Science:
- Ophthalmology
- Virology
- Pathology
Background:
- Epstein-Barr virus (EBV) is a common human herpesvirus.
- Conjunctival involvement by EBV is rare and can present as lymphocytic infiltrates.
Observation:
- Two cases of salmon-colored conjunctival infiltrates were analyzed.
- Patients presented with unilateral or bilateral conjunctival masses.
Findings:
- One patient exhibited ipsilateral preauricular lymphadenopathy and elevated EBV titers, with a unilateral reactive lymphocytic infiltrate.
- The second patient presented with bilateral infiltrates and an expanded clonal B lymphocyte population.
- Both cases demonstrated EBV antigen within the conjunctival lymphocytic infiltrates.
Implications:
- Conjunctival EBV-associated lesions exist on a spectrum from reactive infiltrates to monoclonal B cell populations.
- Understanding this spectrum is crucial for accurate diagnosis and management of ocular EBV infections.