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Conjunctival lymphocytic infiltrates associated with Epstein-Barr virus
A S Feinberg1, C W Spraul, J T Holden
1Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Purpose:
To describe the clinicopathologic features of two patients with Epstein-Barr virus (EBV) associated conjunctival lymphocytic infiltrates.
Design:
Two case reports.
Methods:
The clinical histories and pathologic findings of two patients with salmon-colored conjunctival infiltrates are described.
Main Outcome Measurements:
Clinical observation and pathologic examination of conjunctival biopsy specimens with accompanying immunohistochemical staining, flow cytometric immunophenotyping, and polymerase chain reaction analysis when appropriate.
Results:
One patient had ipsilateral preauricular lymphadenopathy, elevated serum EBV titers, and a unilateral reactive lymphocytic infiltrate resulting in a conjunctival mass. The other patient had bilateral conjunctival lymphocytic infiltrates causing conjunctival masses. There was an expanded clonal population of B lymphocytes in the conjunctival mass in the second patient. Both patients had EBV antigen in their conjunctival lymphocytic infiltrates.
Conclusions:
Conjunctival lymphocytic lesions associated with EBV represent a spectrum of reactive infiltrates to monoclonal populations.