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Related Experiment Videos

St John's wort for depression: a systematic review.

B Gaster1, J Holroyd

  • 1Department of Medicine, University of Washington, Seattle, USA. barakg@u.washington.edu

Archives of Internal Medicine
|January 27, 2000
PubMed
Summary

St. John's wort may be more effective than placebo for mild to moderate depression. However, more research is needed to compare its efficacy against other antidepressants and for severe depression.

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Area of Science:

  • Pharmacology
  • Psychiatry
  • Evidence-based Medicine

Background:

  • St. John's wort is a popular herbal remedy for depression.
  • Its efficacy and safety require rigorous scientific evaluation.

Purpose of the Study:

  • To evaluate the efficacy and safety of St. John's wort for depression.
  • To assess its availability and regulation.

Main Methods:

  • Systematic review of randomized, controlled, double-blind trials.
  • Assessment of methodological quality and data extraction on efficacy, safety, cost, and regulation.

Main Results:

  • Eight high-quality studies suggest St. John's wort is more effective than placebo for mild to moderate depression.
  • Efficacy was lower than tricyclic antidepressants; side effect rates were low.
  • St. John's wort is largely unregulated as a dietary supplement.

Conclusions:

  • St. John's wort shows modest efficacy for mild to moderate depression compared to placebo.
  • Further research is needed for severe depression and comparison with other antidepressants.
  • Regulatory oversight for St. John's wort is under review.

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