Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the Prostate Cancer Outcomes Study
- J L Stanford 1, Z Feng , A S Hamilton , F D Gilliland , R A Stephenson , J W Eley , P C Albertsen , L C Harlan , A L Potosky
- 1Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle 98109-1024, USA. jstanfor@fhcrc.org
- 0Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle 98109-1024, USA. jstanfor@fhcrc.org
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View abstract on PubMed
Summary
This summary is machine-generated.Radical prostatectomy for prostate cancer significantly impacts sexual function, with nearly 60% of men experiencing impotence and over 40% reporting sexual performance issues. Urinary function also declines, highlighting the need for informed patient-physician discussions on treatment complications.
Area Of Science
- Urology
- Oncology
- Public Health
Background
- Limited data exist on prostatectomy complications in population-based cohorts.
- Physicians and patients need comprehensive information on treatment outcomes.
Purpose Of The Study
- To assess changes in urinary and sexual function after radical prostatectomy for localized prostate cancer.
- To provide data on functional outcomes in a diverse patient population.
Main Methods
- Population-based longitudinal cohort study (Prostate Cancer Outcomes Study).
- Follow-up of 1291 men for up to 24 months post-diagnosis.
- Assessment of urinary and sexual function at baseline and at 6, 12, and 24 months.
Main Results
- At 18+ months post-surgery, 8.4% experienced incontinence and 59.9% impotence.
- Impotence rates varied by nerve-sparing technique (56.0%-65.6%).
- Sexual function varied significantly by age and race; urinary function varied by age.
Conclusions
- Radical prostatectomy is linked to substantial erectile dysfunction and some urinary function decline.
- Findings offer crucial insights for physicians and patients navigating prostate cancer treatment choices.
- Age and race are significant factors influencing post-prostatectomy sexual and urinary function.
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