Related Experiment Video
Updated: Aug 19, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Correlation between human papillomavirus-associated cervical cancer and p53 codon 72 arginine/proline polymorphism
R Tachezy1, I Mikysková, M Saláková
1Department of Experimental Virology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
Abstract:
High-risk mucosal human papillomaviruses encode an E6 oncoprotein, which binds the cellular p53 tumor suppressor protein, thereby marking it for degradation through the ubiquitin-mediated pathway. A common p53 polymorphism at codon-72 of exon 4 results in translation to either arginine or proline. Recently reported data suggested an increased susceptibility to E6/ubiquitin-mediated degradation of the Arg72-p53 isoform and an over-representation of the homozygous Arg72-p53 genotype in cervical cancer patients. We have analyzed this polymorphism in a larger series of patients with cervical cancer and in controls in the Czech Republic. We found no statistically significant differences between the codon-72 p53 genotypes of cervical cancer patients and the control women. Based on these results, it is unlikely that Arg72-p53 is associated with an increased risk for human papillomavirus-associated cervical tumor development in Czech women.
Related Concept Videos
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein.
DNA Damage can Stall the Cell Cycle
Single Nucleotide Polymorphisms-SNPs
Abnormal Proliferation
Cancer Prevention
Some...
DNA Damage Can Stall the Cell Cycle

