Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD40-CD40 ligand.

C van Kooten1, J Banchereau

  • 1Department of Nephrology, Leiden University Medical Center, The Netherlands. Kooten@mail.Medfac.LeidenUniv.nl

Journal of Leukocyte Biology
|January 27, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Repeated HLA-DRB1 and HLA-DQB1 Mismatches Without Preformed DSA Affect Graft Survival, Rejection and DSA Development: A Multicenter Analysis.

HLA·2025
Same author

Conversion from calcineurin inhibitors to belatacept-based immunosuppressive therapy skews terminal proliferation of non-classical monocytes and lowers lymphocyte counts.

Transplant immunology·2024
Same author

Presence of CD163<sup>+</sup> macrophages in DCD kidneys with high DGF reduces the risk for acute cellular rejection in 6 months after kidney transplantation.

Transplant immunology·2022
Same author

Is complement the main accomplice in IgA nephropathy? From initial observations to potential complement-targeted therapies.

Molecular immunology·2021
Same author

Effect of seminal plasma on dendritic cell differentiation in vitro depends on the serum source in the culture medium.

Journal of reproductive immunology·2020
Same author

Diagnosis and treatment of C3 glomerulopathy in a center of expertise.

The Netherlands journal of medicine·2019
Same journal

Correction to: IL-27 signaling negatively regulates FcɛRI-mediated mast cell activation and allergic response.

Journal of leukocyte biology·2026
Same journal

Autofluorescence enables detection and quantification of EETosis in human leukocyte cultures.

Journal of leukocyte biology·2026
Same journal

Cold Atmospheric Plasma as an Immunomodulator: Suppression of T-cell Hyperactivation and Graft-versus-Host Disease via Redox Regulation.

Journal of leukocyte biology·2026
Same journal

Distinct lymphocyte immune signatures to nivolumab and recombinant IL-7 ex vivo in patients with sepsis.

Journal of leukocyte biology·2026
Same journal

Eosinophil Essentials: Identification and Assessment of Activity.

Journal of leukocyte biology·2026
Same journal

Immune cell landscape reveals 5 immune-related subtypes and molecular characteristics with prognostic and therapeutic implications in pan-cancer.

Journal of leukocyte biology·2026
See all related articles

CD40, a key immune receptor, and its ligand CD40-L are expressed on many cell types, revealing broader roles in immune regulation beyond B lymphocytes. Their interactions are crucial for diverse immune responses and are being explored in clinical studies.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD40 is a TNF-R family receptor initially identified on B lymphocytes.
  • Its role in T cell-dependent humoral immunity is well-established through genetic studies.
  • Recent findings show broader expression of CD40 and CD40-L on various immune and non-immune cells.

Purpose of the Study:

  • To review recent advancements in CD40 and CD40-L research.
  • To highlight the expanded understanding of CD40-CD40-L interactions in immune regulation.
  • To summarize pre-clinical and clinical studies involving CD40.

Main Methods:

  • Review of literature on CD40 and CD40-L structure and expression.
  • Analysis of studies on CD40 signal transduction pathways.
  • Examination of in vitro and in vivo functional data for CD40/CD40-L interactions.

Related Experiment Videos

Main Results:

  • CD40 and CD40-L are expressed on a wider range of cells than previously known.
  • CD40-CD40-L interactions are implicated in more general immune regulatory functions.
  • Ongoing pre-clinical and clinical studies are investigating these interactions.

Conclusions:

  • CD40-CD40-L interactions play a significant and broad role in immune regulation.
  • Further research is warranted to fully elucidate their functions and therapeutic potential.
  • The expanded understanding of CD40 biology opens new avenues for therapeutic interventions.