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Extirpated uterine endometrial cryoablation with ultrasound visualization
Study Objective:
To determine the efficacy of cryoablation of the uterus monitored by ultrasound.
Design:
Observational research (Canadian Task Force classification II-2).
Setting:
Clinic laboratory.
Subjects:
Eight uteri obtained after hysterectomy.
Intervention:
The uteri were subjected to freeze and thaw cycles in a 37 inverted exclamation markC water bath. Ultrasound was used to monitor the advancing ice front and ice ball diameter.
Measurements And Main Results:
Specimens were sectioned and stained with tetrazolium red to determine the region of nonviable tissue. The maximum average ice ball diameter as measured by ultrasound was 33.2 mm (range 29.1-35.4 mm). The average maximum diameter of nonviable tissue region was 24 mm (range 21.4-28.4 mm), with depth of tissue destruction ranging from 6 to 12 mm.
Conclusion:
Cryosurgery at temperatures below -90 inverted exclamation mark C achieves excellent destruction of uterine tissue and complete destruction of endometrium. Ultrasound can be used to monitor freezing.