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Rheumatoid factor and tumor-host interaction.

J J Twomey, R D Rossen, V M Lewis

    Proceedings of the National Academy of Sciences of the United States of America
    |June 1, 1976
    PubMed
    Summary
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    Rheumatoid factor (RF) seropositivity is common in cancer patients post-treatment, particularly for breast and lung cancers. This suggests RF may indicate tumor-host interactions following specific cancer therapies.

    Area of Science:

    • Oncology
    • Immunology
    • Medical Diagnostics

    Background:

    • Rheumatoid factor (RF) is an autoantibody.
    • RF seropositivity is typically associated with autoimmune diseases like rheumatoid arthritis.
    • The role of RF in neoplastic diseases is less understood.

    Purpose of the Study:

    • To investigate the prevalence of rheumatoid factor (RF) seropositivity in patients with various neoplasms.
    • To determine if RF seropositivity is associated with specific cancer types or treatments.
    • To explore the potential link between RF production and tumor-host interactions.

    Main Methods:

    • Survey of RF seropositivity in patients with neoplasms.
    • Comparison of RF rates between treated and untreated cancer patients.

    Related Experiment Videos

  • Analysis of RF prevalence in patients with breast cancer, lung cancer, glioblastoma, and multiple myeloma.
  • Assessment of RF production in patients undergoing irradiation and/or chemotherapy.
  • Evaluation of RF incidence in renal allograft recipients treated with cytotoxic drugs.

    • Main Results:

    • An 85% rate of positive RF screening tests was observed in certain patient groups.
    • High RF seropositivity (89%) was noted in treated breast cancer patients with no evidence of residual tumor.
    • Elevated RF rates were associated with irradiation and/or chemotherapy for breast and lung cancers.
    • Low RF seropositivity incidence was found in untreated patients with similar tumors and in treated glioblastoma or multiple myeloma patients.
    • Cytotoxic drugs like azathioprine did not directly induce RF production, even in renal allograft recipients.

    Conclusions:

    • RF production frequently occurs after therapy for specific tumors, notably breast and lung cancers.
    • The high incidence of RF seropositivity in treated cancer patients suggests it may be an indicator of tumor-host interaction.
    • RF seropositivity in this context is likely treatment-related rather than a direct effect of cytotoxic drugs alone.