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The penetration of trimethoprim into seminal fluid and serum

H Gnarpe, J Friberg

    Scandinavian Journal of Infectious Diseases. Supplementum
    |January 1, 1976
    PubMed

    Insights

    Trimethoprim reaches therapeutic levels in male serum and seminal fluid. Co-trimoxazole, however, does not impact genital mycoplasma species during treatment.

    Area of Science:

    • Pharmacology
    • Microbiology
    • Urology

    Background:

    • Trimethoprim is an antibiotic used to treat bacterial infections.
    • Understanding drug concentrations in reproductive fluids is crucial for effective treatment and preventing resistance.
    • Genital mycoplasma infections can affect male reproductive health.

    Purpose of the Study:

    • To determine trimethoprim concentrations in seminal fluid and serum of men undergoing treatment.
    • To evaluate the effect of co-trimoxazole on genital mycoplasma species.

    Main Methods:

    • Serum and seminal fluid samples were collected from 18 men during trimethoprim treatment.
    • Trimethoprim concentrations were measured using analytical methods.
    • In vitro susceptibility testing was performed for genital mycoplasma species exposed to co-trimoxazole.

    Main Results:

    • Average serum trimethoprim concentration ranged from 1.8-2.0 µg/mL.
    • Average seminal fluid trimethoprim concentration ranged from 1.0-1.5 µg/mL.
    • Co-trimoxazole showed no inhibitory effect on genital mycoplasma species.

    Conclusions:

    • Trimethoprim achieves concentrations in seminal fluid that may be relevant for treating infections in this compartment.
    • Co-trimoxazole is not effective against genital mycoplasma species and does not influence their growth.

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