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"Figure Eight" Cyclooctapyrroles: Enantiomeric Separation and Determination of the Absolute Configuration of a
Wernerdagger1, Michels, Zander
1Institut für Organische Chemie der Universität, Währinger Strasse 38, A-1090 Wien (Austria).
Angewandte Chemie (International Ed. in English)
|January 29, 2000
Abstract:
The hypothesized racemate separation of cyclooctapyrroles with chiral figure eight conformations-and of metal complexes derived from these ligands-has been realized. The cyclooctapyrrole 1 (as hexadecaethyl derivative), which according to NMR analysis exhibits restricted mobility, and its binuclear palladium and copper complexes could be separated into stable enantiomers by preparative chromatography on a chiral phase. In the case of the palladium complex and the free ligand 1 it was also possible to determine the absolute configuration of the enantiomers.