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Crossreactive neutralizing antibodies induced by immunization with caprine arthritis-encephalitis virus surface
R K Kemp1, D P Knowles, L L Perry
1Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040, USA.
Vaccine
|January 29, 2000
Abstract:
Four Saanen goats were immunized with affinity purified gp135 surface glycoprotein (SU) of caprine arthritis-encephalitis virus isolate 79-63 (CAEV-63) and evaluated for homologous and crossreactive serum neutralizing antibodies. CAEV-63 neutralizing antibodies were detected in all goats after seven immunizations with SU in Quil A adjuvant. Sera from three goats neutralized an independent CAEV isolate (CAEV-Co). However, serum from one goat did not detectably neutralize heterologous CAEV-Co and inhibited CAEV-Co neutralization by another serum.