Management of hyperprolactinemia in infertility

Hyperprolactinemia is a frequent cause of anovulatory sterility, although spontaneous pregnancy may occur occasionally. Dopaminergic treatment is highly effective for both idiopathic and tumoral hyperprolactinemia. If the only cause of infertility is chronic anovulation due to hyperprolactinemia, a 60-80% pregnancy rate can be achieved. These results mean that surgical treatment is still needed only rarely. Either spontaneous or drug-induced pregnancy is usually uneventful for the mother and is not associated with any increase in abortion, twins or malformations. Pregnancy-related tumor growth occurs rarely and can be treated successfully with dopaminergic drugs. Pregnancy frequently leads to some improvement in the biochemical and clinical disorders associated with hyperprolactinemia.