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A cytotoxic 5alpha,8alpha-epidioxysterol from a soft coral Sinularia species
1Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China. sheu@mail.nsysu.edu.tw
Journal of Natural Products
|January 29, 2000
Abstract:
A new sterol, (22R,23R,24R)-5alpha,8alpha-epidioxy-22, 23-methylene-24-methylcholest-6-en-3beta-ol (1), as well as two known sterols, numersterol A (2) and pregnenolone (3), have been isolated from a soft coral Sinularia sp. The structure of metabolite 1 was determined by spectral analysis. Cytotoxicity of sterols 1-3 toward various cancer cell lines is also reported.