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Infantile fibromatosis in childhood: findings on MR imaging and pathologic correlation
1Department of Radiology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea.
Aim:
The objective of this study was to analyse the MR imaging findings of infantile fibromatosis of childhood and to correlate them with histopathological features.
Materials And Methods:
Seven patients with histologically proven infantile fibromatosis were included in this study. The findings on MR images were retrospectively evaluated and then correlated with the pathological features. Findings on MR imaging evaluated included signal intensity, extent of hyperintense area on T2-weighted images, margins of the lesion, the degree and pattern of enhancement and the presence of fatty tissue. Pathological features evaluated included cellularity, collagenization, and myxoid change. A five point scale was used for the evaluation of the extent of hyperintense area on MR imaging, and each of pathological features.
Results:
On T1-weighted images, the lesions were iso-intense in two patients; iso- and hypointense in three; and iso-, hypo- and hyperintense in two. On T2-weighted images, iso-, hypo- and hyperintense areas were mixed in all patients, the hyperintense area being the largest portion of the lesion. The margins of the lesions were infiltrative in four patients (57%), smooth in two (29%) and mixed in one (14%). Enhancement was marked in five patients (72%) and diffuse in five (71%). Regardless of the hyperintense signal intensity on T2-weighted images, the grades of each pathologic feature were variable.
Conclusion:
Infantile fibromatosis on MR imaging causes an enhancing mass, that is largely hyperintense on T2-weighted images. Areas of high signal intensity on T2-weighted images corresponded to variable grades of cellularity, collagenization, or myxoid change.
Insights
Infantile fibromatosis in children presents as an enhancing mass on MR imaging, often showing hyperintensity on T2-weighted images. These bright areas on MRI correlate with varying degrees of cellularity and collagenization in pathology.
Area of Science:
- Pediatric Radiology
- Oncology Imaging
- Soft Tissue Pathology
Background:
- Infantile fibromatosis is a rare benign tumor affecting infants and children.
- Accurate diagnosis relies on integrating imaging and histopathology.
Purpose of the Study:
- To analyze Magnetic Resonance (MR) imaging findings in infantile fibromatosis.
- To correlate MR imaging features with histopathological characteristics.
Main Methods:
- Retrospective analysis of MR imaging in seven patients with confirmed infantile fibromatosis.
- Evaluation of MR imaging features including signal intensity, lesion margins, enhancement, and fatty tissue.
- Correlation with histopathological features: cellularity, collagenization, and myxoid change.
Main Results:
- Lesions showed variable signal intensity on T1-weighted images and mixed signal intensities on T2-weighted images, with hyperintense areas predominating.
- Infiltrative margins were observed in 57% of cases.
- Marked and diffuse enhancement was noted in most patients.
- T2-weighted hyperintensity did not consistently correlate with specific histopathological grades.
Conclusions:
- Infantile fibromatosis typically appears as an enhancing mass on MR imaging, predominantly hyperintense on T2-weighted images.
- T2-weighted hyperintense areas reflect diverse histopathological features like cellularity, collagenization, and myxoid changes.