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Related Experiment Videos

Dopaminergic modulation at the olfactory nerve synapse.

D A Berkowicz1, P Q Trombley

  • 1Laboratory of Computer Science, Harvard University, Boston, MA 02114, USA.

Brain Research
|January 29, 2000
PubMed
Summary
This summary is machine-generated.

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Dopamine, through D2 receptor activation, presynaptically inhibits synaptic transmission between olfactory nerve and olfactory bulb neurons. This modulation affects glutamate receptor activity, impacting olfactory processing.

Area of Science:

  • Neuroscience
  • Olfactory System Research
  • Synaptic Transmission

Background:

  • Dopamine modulates central neuron function, including transmitter release.
  • Dopamine D2 receptors are present in the olfactory bulb (OB), potentially on olfactory nerve (ON) terminals.
  • Olfactory receptor neurons use glutamate to excite OB neurons via NMDA and AMPA/kainate receptors.

Purpose of the Study:

  • To investigate dopamine's modulation of the ON/OB neuron synapse.
  • To determine the mechanism of dopamine's action on synaptic transmission in the OB.

Main Methods:

  • Used a hemisected turtle OB preparation.
  • Employed patch-clamp recording techniques.
  • Administered dopamine, D2 agonist (quinpirole), and D2 antagonist (sulpiride).

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Main Results:

  • Dopamine (10-300 microM) reversibly decreased the excitatory postsynaptic response to ON stimulation.
  • D2 agonist quinpirole mimicked dopamine's inhibitory effect.
  • D2 antagonist sulpiride blocked dopamine's inhibitory effect.
  • Dopamine affected NMDA and AMPA/kainate receptor components but not direct responses to glutamate, kainate, or NMDA.

Conclusions:

  • Dopamine modulates synaptic transmission between olfactory receptor neurons and OB neurons.
  • The mechanism involves presynaptic D2 receptor activation.
  • This suggests a role for dopamine in regulating olfactory information processing at the initial synapse.