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Published on: September 30, 2014
Streptococcus mutans strain N produces a novel low molecular mass non-lantibiotic bacteriocin
M Balakrishnan1, R S Simmonds, A Carne
1Department of Microbiology, University of Otago, Dunedin, New Zealand.
Abstract:
Streptococcus mutans strain N was shown to have bacteriocin production and immunity characteristics consistent with those of Group I mutacin-producing strains of S. mutans. The bacteriocin mutacin N was purified from agar cultures of S. mutans strain N using XAD andp6 reversed phase chromatography. The molecular mass of mutacin N was 4806 Da and the entire 49 amino acid sequence was determined by N-terminal sequencing. Database searches indicate that mutacin N is a novel bacteriocin, but with some homology to the protein IIC domain of a hypothetical sugar-phosphotransferase enzyme from Acholeplasma florum.
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