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Prothrombotic risk factors in childhood stroke and venous thrombosis

C Heller1, S Becker, I Scharrer

  • 1Department of Paediatrics, Johann Wolfgang Goethe University, Frankfurt am Main, Germany. cheller@uni-frankfurt.de

European Journal of Pediatrics
|January 29, 2000
PubMed

Insights

FV Leiden mutation and protein C deficiency increase the risk of cerebral infarction and venous thrombosis in children. These thrombophilias are significant risk factors for pediatric stroke, unlike in adults.

Area of Science:

  • Pediatric Hematology
  • Neurology
  • Thrombosis Research

Background:

  • Venous thromboses in children are often linked to hematological disorders.
  • Studies on hemostasis disorders influencing pediatric stroke are scarce.
  • Investigating prothrombotic risk factors in pediatric stroke is crucial.

Purpose of the Study:

  • To compare prothrombotic risk factors in children with cerebral infarction versus venous thrombosis.
  • To assess the prevalence of specific thrombophilias in these pediatric patient groups.
  • To determine the association of thrombophilias with pediatric stroke and venous thrombosis.

Main Methods:

  • Comparative analysis of 26 children with cerebral infarction and 17 with venous thrombosis.
  • Screening for prothrombotic risk factors including FV Leiden mutation and protein C deficiency.
  • Comparison of patient group prevalences with 150 healthy pediatric controls.

Main Results:

  • FV Leiden mutation and/or protein C deficiency were found in 26.9% of cerebral infarction patients and 53% of venous thrombosis patients.
  • These thrombophilias significantly increased the risk of cerebral infarction (OR 5.77) and venous thrombosis (OR 19.9) in children compared to controls.
  • The association of thrombophilia with cerebral infarction in children contrasts with findings in adult patients.

Conclusions:

  • FV Leiden mutation and protein C deficiency are identified as potential contributors to the multifactorial etiology of early childhood stroke.
  • These findings highlight the importance of screening for thrombophilias in pediatric stroke cases.
  • The results underscore differences in thrombophilia's role in pediatric versus adult cerebral infarction.
Abstract

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