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Related Experiment Videos

Plasma values for u-PA in children.

P Zeitler1, V Schuster

  • 1Department of Paediatrics, University of Würzburg, Germany. kink111@rzkli.uni-wuerzburg.de

European Journal of Pediatrics
|January 29, 2000
PubMed
Summary
This summary is machine-generated.

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Urokinase-type plasminogen activator (u-PA) levels in healthy children are similar to adult values. This study establishes normal pediatric u-PA plasma concentrations for the first time.

Area of Science:

  • Biochemistry
  • Pediatric Medicine
  • Hematology

Background:

  • Urokinase-type plasminogen activator (u-PA) is crucial for plasminogen activation, tissue remodeling, angiogenesis, cell migration, and tumor metastasis.
  • Elevated u-PA levels are observed in adults with chronic liver disease.
  • No data on u-PA plasma levels in pediatric populations currently exist.

Purpose of the Study:

  • To determine normal urokinase-type plasminogen activator (u-PA) plasma levels in healthy children and adolescents.
  • To compare pediatric u-PA levels with those reported in adults.
  • To investigate u-PA levels in children with type I plasminogen deficiency.

Main Methods:

  • Plasma samples were collected from 95 healthy children and adolescents (aged 7 months to 17 years).

Related Experiment Videos

  • Urokinase-type plasminogen activator (u-PA) levels were quantified using enzyme-linked immunosorbent assay (ELISA).
  • u-PA levels were also measured in 16 pediatric patients with type I plasminogen deficiency.

    • Main Results:

    • The median u-PA plasma level in healthy children was 1.06 ng/ml (range: 0.43-15.78 ng/ml), comparable to adult values.
    • No significant differences in u-PA levels were observed between males and females.
    • Children with type I plasminogen deficiency showed a median u-PA level of 1.06 ng/ml (range: 0.69-7.7 ng/ml).

    Conclusions:

    • Normal plasma urokinase-type plasminogen activator (u-PA) values in healthy children and adolescents are similar to those found in adults.
    • These findings provide a reference range for pediatric u-PA levels.
    • Pediatric plasminogen deficiency does not appear to significantly alter u-PA plasma levels compared to healthy children.