Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complex cadherin expression in human prostate cancer cells.

M J Bussemakers1, A Van Bokhoven, K Tomita

  • 1Urology Research Laboratory, University Hospital Nijmegen, The Netherlands.

International Journal of Cancer
|February 1, 2000
PubMed
Summary

Loss of E-cadherin and increased expression of other cadherins, such as N-cadherin and cadherin-11, drive prostate cancer progression and metastasis. These changes in cell adhesion molecules are key to invasive phenotypes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world effectiveness of molecular-matched therapies in salivary gland cancer.

ESMO open·2026
Same author

Upregulation of miR-3195, miR-3687 and miR-4417 is associated with castration-resistant prostate cancer.

World journal of urology·2021
Same author

Systemic therapy in the management of recurrent or metastatic salivary duct carcinoma: A systematic review.

Cancer treatment reviews·2020
Same author

Improving the barrier function of damaged cultured urothelium using chondroitin sulfate.

Neurourology and urodynamics·2019
Same author

Adjuvant androgen deprivation therapy for poor-risk, androgen receptor-positive salivary duct carcinoma.

European journal of cancer (Oxford, England : 1990)·2019
Same author

Blood-based and urinary prostate cancer biomarkers: a review and comparison of novel biomarkers for detection and treatment decisions.

Prostate cancer and prostatic diseases·2016

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Cell-cell interactions are crucial in cancer progression.
  • Loss of E-cadherin expression correlates with poor prognosis in prostate cancer.
  • E-cadherin loss alone doesn't fully explain invasive phenotypes.

Purpose of the Study:

  • Investigate the role of other cadherins in prostate cancer progression.
  • Identify cadherins involved in invasive and metastatic phenotypes.
  • Determine the impact of altered cadherin expression on clinical outcomes.

Main Methods:

  • Used degenerate cloning to identify conserved cadherin sequences.
  • Analyzed cadherin expression in human prostate cancer cells.
  • Correlated cadherin expression with invasive phenotypes.

Related Experiment Videos

Main Results:

  • Identified expression of N-cadherin, P-cadherin, cadherin-4, -6, and -11 in prostate cancer cells.
  • Found that upregulation of certain cadherins contributes to invasiveness.
  • Highlighted N-cadherin and cadherin-11 as particularly important in prostate cancer progression.

Conclusions:

  • Prostate cancer progression involves both E-cadherin loss and altered expression of other cadherins.
  • N-cadherin and cadherin-11 upregulation are significant factors in prostate cancer invasiveness and metastasis.