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Updated: Aug 2, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry
Published on: October 8, 2012
Role of the common cytokine receptor gamma chain (gammac) in thymocyte selection
H Nakajima1, M Noguchi, W J Leonard
1Dept of Internal Medicine II, Chiba University School of Medicine, Chiba 260-8670, Japan.
Abstract:
During thymocyte development, T-cell receptor (TCR) alphabeta-mediated intracellular signals can elicit two entirely different cellular responses: positive selection (resulting in rescue from death and maturation or differentiation) and negative selection (induction of apoptosis). Here, Hiroshi Nakajima and colleagues discuss how survival signals that are dependent on the common cytokine receptor gamma chain (gammac) might affect the TCR-driven selection process in thymocytes, underscoring the potential role of cytokines in this process.
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