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Is CREB a key to neuronal survival?

M R Walton1, I Dragunow

  • 1Dept of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Trends in Neurosciences
|February 1, 2000
PubMed
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The transcription factor cAMP-response-element-binding protein (CREB) may be responsible for programmed nerve cell survival. Further research is needed to confirm CREB's role in the brain and identify its downstream survival genes.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Nerve-cell survival in the brain is regulated by various molecules.
  • Many neuroprotective molecules may function by activating the transcription factor cAMP-response-element-binding protein (CREB).

Purpose of the Study:

  • To investigate the role of CREB in programmed nerve-cell survival.
  • To identify downstream survival genes regulated by CREB in neurons.

Main Methods:

  • The study reviews existing research on CREB activation and its effects on cell survival.
  • Focuses on in vitro findings and suggests in vivo studies.

Main Results:

  • CREB activation, through phosphorylation at Ser133, occurs in resistant hippocampal cells and is triggered by stimuli.

Related Experiment Videos

  • The Akt signaling pathway activates CREB, promoting survival in vitro.
  • CREB synthesis and phosphorylation enhance survival of various cells, including neurons.

    • Conclusions:

    • CREB is a potential key player in programmed nerve-cell survival.
    • Further in vivo studies are required to validate these findings in the brain.
    • Identification of CREB-activated downstream survival genes in neurons is crucial.