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Malaria complicating neoplastic disease.

M L Tapper, D Armstrong

Archives of Internal Medicine

|July 1, 1976

Summary

This summary is machine-generated.

Transfusion-induced malaria occurred in two cancer patients. Despite underlying conditions and treatments, both responded well to antimalarial drugs, showing significant antibody development.

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Area of Science:

Infectious Diseases
Oncology
Hematology

Background:

Neoplastic diseases can compromise immune function, increasing susceptibility to opportunistic infections.
Transfusion-transmitted infections, including malaria, pose a risk in immunocompromised patients.
The interaction between malignancy, chemotherapy, and parasitic infections requires further investigation.

Observation:

Two patients with cancer (acute myelogenous leukemia and metastatic colon carcinoma) developed transfusion-induced malaria.
One patient had Plasmodium vivax infection, while the other had Plasmodium malariae.
The patient with colon carcinoma had undergone splenectomy, a procedure known to increase infection risk.

Findings:

Neither the acute myelogenous leukemia nor intensive chemotherapy affected the clinical course of P. vivax malaria.

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The P. malariae infection in the splenectomized patient presented as a severe, cerebral malaria-like illness.

Both patients demonstrated dramatic clinical responses to antimalarial chemotherapy.

Both patients developed notable antibody responses post-treatment.

Implications:

Transfusion-induced malaria is a significant concern in cancer patients, regardless of their specific malignancy or treatment.
Splenectomy may exacerbate the severity of malaria infections.
Prompt diagnosis and treatment with antimalarial chemotherapy are crucial for favorable outcomes.
The development of antibody responses suggests the potential for long-term immunity, even in immunocompromised individuals.