Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Programmed cell death in colorectal carcinogenesis.

A M Valentini1, M L Caruso, R Armentano

  • 1Department of Histopathology, IRCCS S. De Bellis, Castellana Grotte, Bari, Italy.

Anticancer Research
|February 1, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A straightforward method for assessing the technical image quality of reconstructed and synthetic 2D images for Digital breast tomosynthesis systems.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2025
Same author

Detection of cardiac arrhythmia patterns in ECG through H × C plane.

Chaos (Woodbury, N.Y.)·2023
Same author

Red cell distribution width is a potential predictor of early relapse in polymyalgia rheumatica.

Reumatismo·2021
Same author

Impact of <i>Phyllantus niruri</i> and <i>Lactobacillus amylovorus</i> SGL 14 in a mouse model of dietary hyperoxaluria.

Beneficial microbes·2020
Same author

Impact of the COVID-19 outbreak on an Italian cohort of systemic sclerosis patients.

Scandinavian journal of rheumatology·2020
Same author

TNF-α inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood pressure.

Biochemical pharmacology·2020
Same journal

Corrigendum.

Anticancer research·2026
Same journal

Geographic Variation in Stage at Diagnosis of Skin Cancer in the United States: A National Cancer Database Analysis.

Anticancer research·2026
Same journal

Anti-tumor Effects of Loureirin A Treatment in Colorectal Cancer Cells <i>via</i> Inhibition of AKT Phosphorylation.

Anticancer research·2026
Same journal

Bayesian Analysis to Refine East Asian Subgroup Estimates in the CLEAR Trial (Lenvatinib Plus Pembrolizumab <i>vs</i>. Sunitinib) for Advanced Renal Cell Carcinoma.

Anticancer research·2026
Same journal

Pulsed Electromagnetic Field Increases Doxorubicin-induced Mitotic Slippage in MDA-MB-231 Breast Cancer Cells.

Anticancer research·2026
Same journal

Geographic Disparities in Socioeconomic Factors and Advanced-stage Presentation in Rectosigmoid Cancer: A National Cancer Database Analysis.

Anticancer research·2026
See all related articles

Early bcl-2 gene activation, not p53 mutation, inhibits programmed cell death (apoptosis) in colorectal cancer. This leads to increased cell proliferation and accumulation of long-living cells, promoting cancer development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gastroenterology

Background:

  • Cell proliferation is a key mechanism in malignant transformation.
  • Understanding the roles of apoptosis and related genes (p53, bcl-2) is crucial in colorectal carcinogenesis.

Purpose of the Study:

  • To investigate the relationship between programmed cell death (apoptosis), cell proliferation, and the expression of apoptosis regulatory genes (p53 and bcl-2) during colorectal cancer development.

Main Methods:

  • Comparative analysis of gene expression (p53, bcl-2) and cell proliferation/apoptosis rates.
  • Study included normal colonic epithelium, sporadic adenomas (early and late), familial adenomatous polyposis (FAP) adenomas, and carcinomas.

Main Results:

  • Programmed cell death decreased, while cell proliferation increased from adenoma to carcinoma.

Related Experiment Videos

  • p53 expression rose significantly from early to late adenomas, while bcl-2 staining decreased.
  • bcl-2 expression was higher in FAP adenomas than sporadic cases, suggesting a role in accumulating long-living cells prone to mutations.

    • Conclusions:

    • Abnormal early activation of bcl-2, rather than late p53 mutation, appears to inhibit apoptosis in colorectal carcinogenesis.
    • The findings suggest bcl-2 plays a significant role in the early stages of colorectal cancer development by promoting cell survival.