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Paget's disease in identical twins.

R A Melick, T J Martin

    Australian and New Zealand Journal of Medicine
    |December 1, 1975
    PubMed
    Summary

    Paget

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    Area of Science:

    • Genetics and Bone Biology
    • Epidemiology of Skeletal Diseases

    Background:

    • Paget's disease of bone is a chronic skeletal disorder characterized by abnormal bone remodeling.
    • Etiology remains multifactorial, with genetic predisposition playing a significant role.

    Observation:

    • A case study involving elderly monozygotic twin sisters diagnosed with Paget's disease of bone.
    • Both twins presented with skull involvement, but exhibited distinct patterns of other affected bones.

    Findings:

    • This report documents the fifth instance of Paget's disease of bone in identical twins.
    • The concordance of the disease in twins suggests a strong genetic influence, despite varied skeletal manifestations.

    Implications:

    • Further research into genetic factors contributing to Paget's disease is warranted.
    • Understanding twin concordance aids in elucidating the genetic architecture of complex skeletal disorders.