Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumor therapy and track structure.

G Kraft1, M Scholz, U Bechthold

  • 1GSI, Biophysik, Darmstadt, Germany. G.Kraft@gsi.de

Radiation and Environmental Biophysics
|February 2, 2000
PubMed
Summary

Heavy ions like carbon offer higher relative biological effectiveness (RBE) for radiotherapy due to their unique track structure. This study details RBE calculation for improved heavy-ion tumor treatment planning.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Proper lighting for color vision testing: The TRUE COLOR LED lamp - an innovation in this field].

Journal francais d'ophtalmologie·2020
Same author

Biological responses to extreme weather events are detectable but difficult to formally attribute to anthropogenic climate change.

Scientific reports·2020
Same author

Two-level ACDF with a zero-profile stand-alone spacer compared to conventional plating: a prospective randomized single-center study.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2020
Same author

Does zinc supplementation enhance the clinical efficacy of chloroquine/hydroxychloroquine to win today's battle against COVID-19?

Medical hypotheses·2020
Same author

Drivers of changing urban flood risk: A framework for action.

Journal of environmental management·2019
Same author

Is Optical Coherence Tomography a Potential Tool to Evaluate Marginal Adaptation of Class III/IV Composite Restorations <i>In Vivo</i>?

Operative dentistry·2018

Area of Science:

  • Medical physics
  • Radiation biology
  • Radiotherapy

Background:

  • Heavy ions, such as carbon, exhibit high relative biological effectiveness (RBE) in radiotherapy.
  • This elevated RBE stems from the microscopic dose distribution within particle tracks, leading to potentially irreparable lesions.

Purpose of the Study:

  • To investigate the relationship between heavy-ion track structure, biological repair capacity, and RBE.
  • To apply these findings to enhance treatment planning for heavy-ion radiotherapy.

Main Methods:

  • Utilizing the local effect model (LEM) for calculations.
  • Analyzing radial dose distribution dependence on particle energy and atomic number.
  • Incorporating x-ray dose response to model biological repair capacity.

Main Results:

  • Developed a method to calculate particle irradiation response based on physical and biological factors.
  • Demonstrated the application of the local effect model (LEM) in treatment planning.

Conclusions:

  • The study successfully links electron emission, track structure, and RBE calculation.
  • The local effect model (LEM) provides a framework for optimizing heavy-ion radiotherapy treatment plans by considering beam quality and tissue sensitivity.

Related Experiment Videos