Related Experiment Video
Updated: Jul 2, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Can Reed-Sternberg cells of classic Hodgkin's disease be considered B-cells?
A Carbone1, A Gloghini, G Gaidano
1Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, 33081, Italy. acarbone@ets.it
Abstract:
During the last twenty years, the issue of the nature of Reed-Sternberg (RS) cells of Hodgkin's disease (HD) has been addressed by multiple methodological approaches. In recent times, a major insight into HD has been obtained through molecular studies of isolated cells which have proven the clonal nature of HD. In parallel to molecular investigations some novel biologic markers specifically associated with the different stages of mature B-cells have helped to define the cellular origin of HD. This review deals with histological features of HD and summarizes recent results from molecular and immunohistochemical studies focusing on the origin and the stage of differentiation of RS cells.
More Related Videos
09:01Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
08:44Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Related Concept Videos
Multipotency of Hematopoietic Stem Cells
Production of Formed Elements
Most HSCs commit to...
Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...