Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chlorhexidine release from room temperature polymerising methacrylate systems.

P D Riggs1, M Braden, M Patel

  • 1Department of Biomaterials in Relation to Dentistry, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary Westfield College, University of London, UK.

Biomaterials
|February 3, 2000
PubMed
Summary

This study shows that tetrahydrofurfuryl methacrylate-based polymers release more chlorhexidine due to channel formation. Higher dimethyl-p-toluidine (DMPT) content increased residual monomer leaching.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Crystal structure and absence of magnetic order in single-crystalline RuO<sub>2</sub>.

Journal of physics. Condensed matter : an Institute of Physics journal·2025
Same author

Rotational phase transitions in antifluorite-type osmate and iridate compounds.

Journal of physics. Condensed matter : an Institute of Physics journal·2024
Same author

Combined Arrhenius-Merz Law Describing Domain Relaxation in Type-II Multiferroics.

Physical review letters·2021
Same author

Interplay of Electronic and Spin Degrees in Ferromagnetic SrRuO_{3}: Anomalous Softening of the Magnon Gap and Stiffness.

Physical review letters·2019
Same author

Spin Fluctuations in Sr_{2}RuO_{4} from Polarized Neutron Scattering: Implications for Superconductivity.

Physical review letters·2019
Same author

Control of Chiral Magnetism Through Electric Fields in Multiferroic Compounds above the Long-Range Multiferroic Transition.

Physical review letters·2017

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomaterials

Background:

  • Methacrylate monomers form room temperature curing systems when gelled with poly(ethyl methacrylate) powder containing benzoyl peroxide.
  • Chlorhexidine diacetate is an antimicrobial agent often incorporated into dental materials.
  • Understanding drug release mechanisms and polymerization effects is crucial for biomaterial development.

Purpose of the Study:

  • To investigate the release of chlorhexidine diacetate from various methacrylate monomers.
  • To explore the impact of chlorhexidine doping on methacrylate polymerization.
  • To analyze the effect of dimethyl-p-toluidine (DMPT) concentration on polymer properties and leaching.

Main Methods:

  • Gelling of different methacrylate monomers with poly(ethyl methacrylate) powder and benzoyl peroxide.

Related Experiment Videos

  • Doping polymer samples with 5.625% chlorhexidine diacetate.
  • Utilizing Nuclear Magnetic Resonance (NMR) spectroscopy to analyze released substances and residual monomers.

    • Main Results:

    • Tetrahydrofurfuryl methacrylate-based polymers exhibited significantly greater chlorhexidine diacetate release, attributed to channel formation.
    • Chlorhexidine doping hindered polymerization, leading to increased leaching of residual monomers and low molecular weight components.
    • Higher concentrations of dimethyl-p-toluidine (2.5% DMPT) resulted in greater leaching of unpolymerized components.

    Conclusions:

    • Tetrahydrofurfuryl methacrylate is a promising base for drug delivery systems requiring substantial chlorhexidine release.
    • Polymerization inhibition by chlorhexidine and DMPT necessitates careful formulation to minimize leaching of unreacted monomers.
    • The study highlights the interplay between monomer structure, dopant concentration, and resulting polymer properties for controlled release applications.