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Related Experiment Videos

Cataract incidence after total-body irradiation.

D Zierhut1, F Lohr, P Schraube

  • 1Department of Clinical Radiology, University of Heidelberg, Germany. dietmar_zierhut@med.uni-heidelberg.de

International Journal of Radiation Oncology, Biology, Physics
|February 3, 2000
PubMed
Summary

Cataract is a common side effect following total-body irradiation (TBI). This study found a 32.9% incidence of cataract in patients undergoing TBI and stem cell transplantation, comparable to other centers.

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Area of Science:

  • Oncology
  • Ophthalmology
  • Radiotherapy

Background:

  • Hematological malignancies often require intensive treatment regimens.
  • Total-body irradiation (TBI) followed by stem cell transplantation is a standard therapeutic approach.
  • Cataract is a known potential complication of radiation therapy.

Purpose of the Study:

  • To evaluate the incidence of cataract in patients treated with TBI and autologous stem cell transplantation.
  • To assess long-term ocular side effects in a homogeneously treated patient cohort.

Main Methods:

  • Retrospective analysis of 260 patients treated between 1982 and 1994.
  • Focus on 209 patients who received hyperfractionated TBI (median 14.4 Gy).
  • Ophthalmological examination and questionnaire data from 86 surviving patients with a median follow-up of 5.8 years.

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Main Results:

  • Cataract developed in 32.9% (28/85) of patients after a median of 47 months post-TBI.
  • Median patient age at TBI was 38.5 years.
  • No statistically significant difference in cataract incidence was observed based on prior whole-brain irradiation.

Conclusions:

  • Cataract is a frequent adverse event after TBI.
  • The observed cataract incidence aligns with findings from other institutions using fractionated TBI protocols.
  • Long-term follow-up is crucial for accurately determining cataract incidence post-TBI.