Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intensity modulation for breast treatment using static multi-leaf collimators.

Y C Lo1, G Yasuda, T J Fitzgerald

  • 1Radiation Oncology, University of Massachusetts Medical Center, Worcester, MA 01655, USA. LOY@UMMHC.ORG

International Journal of Radiation Oncology, Biology, Physics
|February 3, 2000
PubMed
Summary

Multi-leaf collimator (MLC) fields improve breast cancer treatment dose uniformity. This intensity modulation technique reduces hot spots and spares organs at risk, enhancing patient outcomes with minimal setup changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Importance of quality assurance in radiation oncology clinical trials.

Frontiers in oncology·2026
Same author

Radiation Therapy Quality Assurance Analysis of Alliance A021501: Preoperative mFOLFIRINOX or mFOLFIRINOX Plus Hypofractionated Radiation Therapy for Borderline Resectable Adenocarcinoma of the Pancreas.

International journal of radiation oncology, biology, physics·2024
Same author

Retrotracheal space width as potential novel predictor for congenital esophageal atresia.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023
Same author

Erectile Dysfunction and End-Stage Kidney Disease.

Irish medical journal·2023
Same author

Editorial: Rising stars in radiation oncology 2022.

Frontiers in oncology·2023
Same author

Report of the Medical Image De-Identification (MIDI) Task Group -- Best Practices and Recommendations.

ArXiv·2023

Area of Science:

  • Radiation Oncology
  • Medical Physics

Background:

  • Breast cancer treatment often faces challenges with achieving uniform radiation dose distributions.
  • Traditional techniques can lead to areas of under- or over-dosing, impacting treatment efficacy and side effects.

Purpose of the Study:

  • To enhance dose uniformity in breast cancer radiotherapy using multiple sets of multi-leaf collimator (MLC) defined fields.
  • To reduce "hot" dose regions commonly observed in conventional breast cancer treatments.

Main Methods:

  • Utilized CT scans for target volume delineation and 3D treatment planning.
  • Employed MLCs without collimator rotation to shape tangential fields, optimizing for lung sparing.
  • Implemented a sequential delivery of multiple static MLC fields with adjusted weights to modulate intensity and improve dose distribution.

Related Experiment Videos

Main Results:

  • Achieved significant improvement in dose uniformity, reducing high-dose areas from 7%-22% to approximately 7%-15%.
  • Observed a decrease in the volume of tissue receiving high doses, with these regions shifting from the lung to the target volume.
  • Demonstrated the ability to treat internal mammary nodes without significant inclusion of lung or heart tissue.

Conclusions:

  • Intensity modulation with static MLC fields offers a viable method for improving dose uniformity in select breast cancer patients.
  • This technique effectively reduces "hot" dose regions in the breast and minimizes lung irradiation.
  • The approach offers no increase in setup complexity and only an insignificant increase in treatment time.