Likelihood of undergoing genetic testing for cancer risk: a population-based study
K Bosompra1, B S Flynn, T Ashikaga
1Department of Medical Biostatistics, University of Vermont, Burlington,Vermont 05405, USA. kwadwo.bosompra@uvm.edu
Preventive Medicine
|February 5, 2000
Summary
Public perceptions of cancer genetic susceptibility testing are influenced by perceived benefits, barriers, susceptibility, and pessimism. These factors also mediate the impact of demographics and awareness on testing likelihood.
Area of Science:
- Genetics
- Public Health
- Behavioral Science
Background:
- Limited research exists on general population perceptions of cancer genetic susceptibility testing.
- Existing studies often focus on specific cancers or high-risk groups.
Purpose of the Study:
- To develop and test a psychosocial model for understanding influences on cancer genetic susceptibility testing uptake.
- To examine proximal and distal factors affecting the likelihood of undergoing genetic testing for cancer risk in a general population sample.
Main Methods:
- A population-based sample of 622 adults (aged 18-75) was surveyed via telephone.
- Measures were adapted from the Health Belief Model and existing literature.
- Structural equation modeling was employed for data analysis.
Main Results:
- Perceived benefits, barriers, susceptibility, and pessimism independently affected testing likelihood.
- Age, socioeconomic status, family history of cancer, and awareness also influenced uptake.
- The model explained 34% of the variance in the likelihood of undergoing genetic susceptibility testing.
Conclusions:
- Perceived benefits, barriers, susceptibility, and pessimism directly impact decisions about cancer genetic testing.
- These psychosocial factors may also mediate the influence of demographic and awareness variables on testing likelihood.
- Understanding these influences is crucial for public health communication regarding genetic susceptibility testing for cancer.
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