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Related Experiment Videos

Mapping quantitative trait loci for bovine ovulation rate.

B W Kirkpatrick1, B M Byla, K E Gregory

  • 1Department of Animal Sciences, University of Wisconsin-Madison, 53706, USA.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|February 5, 2000
PubMed
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Researchers identified quantitative trait loci (QTL) for ovulation rate in cattle. Significant QTL were found on chromosomes 5 and 19, with evidence suggesting two QTL on chromosome 7.

Area of Science:

  • Animal Genetics
  • Quantitative Trait Loci (QTL) Analysis
  • Reproductive Biology

Background:

  • Previous studies suggested quantitative trait loci (QTL) for ovulation rate on bovine Chromosome 7.
  • A genome-wide search for ovulation rate QTL was initiated in an elite, three-generation cattle family.
  • Understanding genetic control of ovulation rate is crucial for improving reproductive efficiency in livestock.

Purpose of the Study:

  • To continue investigating evidence for ovulation rate QTL on bovine Chromosome 7.
  • To extend the genome-wide search for QTL influencing ovulation rate.
  • To test the hypothesis of one versus two QTL on Chromosome 7.

Main Methods:

  • Interval mapping and selective genotyping were employed using an elite three-generation cattle family.

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  • Additional genetic markers were typed on Chromosome 7 to refine QTL localization.
  • Genome screening with 14 informative markers identified potentially significant chromosomal regions for further analysis.

    • Main Results:

    • Interval mapping provided suggestive evidence for QTL on Chromosome 7 (nominal P<0.00077).
    • Analysis supported the presence of two QTL on Chromosome 7 (P<0.05), rather than one.
    • Significant evidence for ovulation rate QTL was found on Chromosomes 5 and 19 (P<0.000026); Chromosome 10 showed suggestive but not significant linkage.

    Conclusions:

    • This study confirmed and refined the location of ovulation rate QTL on bovine Chromosome 7.
    • Novel QTL for ovulation rate were identified on Chromosomes 5 and 19.
    • These findings contribute to understanding the genetic architecture of reproductive traits in cattle.