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Related Experiment Videos

Steroid hormone receptor expression and action in bone.

R Bland1

  • 1Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K. R.Bland@bham.ac.uk

Clinical Science (London, England : 1979)
|February 5, 2000
PubMed
Summary

Steroid hormones and related compounds are crucial for bone health, acting through nuclear receptors to regulate bone remodeling and cell development. Understanding these mechanisms is key to maintaining skeletal architecture.

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Molecular Biology

Background:

  • Bone remodeling is a complex process intricately regulated by hormonal signals.
  • The role of steroid hormones in bone cell development and skeletal architecture is well-established.
  • Recent advancements allow for a detailed understanding of steroid hormone mechanisms of action.

Purpose of the Study:

  • To review the actions of steroid hormones (oestrogens, corticosteroids, androgens, progesterone) and related compounds (vitamin D, thyroid hormone, retinoids) on bone.
  • To provide an overview of current knowledge on steroid hormone action in bone, integrating in vivo and in vitro data.
  • To include a comprehensive review of steroid hormone receptor expression in bone cells.

Main Methods:

  • Review of existing literature on steroid hormone action in bone.

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  • Examination of in vivo and in vitro studies.
  • Analysis of data on steroid hormone receptor expression in bone cells.

    • Main Results:

    • Steroid hormones and related compounds, acting via nuclear receptors of the steroid/thyroid receptor superfamily, significantly influence bone cell development and function.
    • These hormones are critical for maintaining normal bone architecture and regulating bone remodeling.
    • Expression patterns of steroid hormone receptors in bone cells have been documented.

    Conclusions:

    • A comprehensive understanding of steroid hormone action is essential for bone health.
    • Further research, including studies using knockout mouse models, will enhance our knowledge of these hormonal effects on bone.
    • Targeting steroid hormone pathways offers potential therapeutic strategies for bone-related disorders.