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Risk factors for multiple intracranial aneurysms
1Department of Neurosurgery, Helsinki University Central Hospital, Finland. seppo.juvela@helsinki.fi
Stroke
|February 5, 2000
Summary
Regular cigarette smoking is a significant risk factor for multiple intracranial aneurysms. Age and female sex may also increase risk in patients with subarachnoid hemorrhage.
Area of Science:
- Neurology
- Vascular Surgery
- Epidemiology
Background:
- Multiple intracranial aneurysms present unique risk factors for formation.
- Limited research exists on independent risk factors for multiple aneurysms.
- Contradictory findings necessitate further investigation into these factors.
Purpose of the Study:
- Identify independent risk factors for multiple intracranial aneurysms.
- Focus on patients who have experienced subarachnoid hemorrhage.
- Differentiate formation risk factors from rupture risk factors.
Main Methods:
- Compared 80 patients with multiple aneurysms to those with single aneurysms.
- Analyzed 266 patients with aneurysmal subarachnoid hemorrhage.
- Utilized multiple logistic regression to assess health habits, diseases, and medications.
Main Results:
- Regular cigarette smoking was a significant independent risk factor (OR 2.06).
- Age and female sex showed a tendency to increase risk for multiple aneurysms.
- Hypertension was associated with more aneurysms but not necessarily multiple aneurysms.
Conclusions:
- Cigarette smoking is a key risk factor for multiple intracranial aneurysms.
- Age and female sex may also contribute to the development of multiple aneurysms.
- Hypertension correlates with a higher aneurysm burden.