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Dopamine D(2) receptor ribozyme inhibits quinpirole-induced stereotypy in rats
P Salmi1, B S Sproat, J Ludwig
1Center for Genomics Research, Karolinska Institutet, 171 77, Stockholm, Sweden.
European Journal of Pharmacology
|February 5, 2000
Abstract:
The injection of a dopamine D(2) receptor hammerhead ribozyme (20 microg) once daily for 5 days into the nucleus accumbens of rats resulted in an inhibition of stereotyped sniffing and locomotor activation produced by the selective dopamine D(2) receptor agonist, quinpirole (0.4 mg kg(-1) s.c.). The results suggest that ribozymes may be useful in the study of in vivo gene function in the brain.