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Related Experiment Videos

Regulation of trabecular meshwork contractility.

F Stumpff1, M Wiederholt

  • 1Institut für Klinische Physiologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Deutschland.

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|February 5, 2000
PubMed
Summary

Trabecular meshwork cells exhibit smooth muscle-like properties, responding to drugs that alter intraocular pressure. Agents relaxing trabecular meshwork show promise for improving glaucoma therapy.

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Mechanisms of action of unoprostone on trabecular meshwork contractility.

Investigative ophthalmology & visual science·2001

Area of Science:

  • Ocular Physiology
  • Pharmacology
  • Cell Biology

Background:

  • The trabecular meshwork (TM) is crucial for regulating intraocular pressure (IOP).
  • TM cells possess smooth muscle-like characteristics, influencing aqueous humor outflow.
  • Understanding TM cell behavior is key to developing effective glaucoma treatments.

Purpose of the Study:

  • To investigate the smooth muscle-like properties of trabecular meshwork cells.
  • To explore the cellular mechanisms underlying TM contraction and relaxation.
  • To identify potential pharmacological targets for glaucoma therapy.

Main Methods:

  • Utilized bovine and primate eye models for pharmacological studies.
  • Performed cellular-level analysis including membrane voltage measurements.

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  • Conducted intracellular calcium level assessments and patch-clamp experiments.

    • Main Results:

    • Pharmacological agents can induce contraction and relaxation in trabecular meshwork.
    • TM contraction correlates with depolarization and increased intracellular calcium.
    • TM relaxation involves maxi-K channel stimulation, hyperpolarization, and L-type calcium channel closure.
    • Human and bovine TM cells showed no significant functional differences.

    Conclusions:

    • Trabecular meshwork cells exhibit pharmacologically responsive smooth muscle-like properties.
    • Mechanisms of TM relaxation, involving ion channels, offer potential therapeutic avenues.
    • Pharmacological agents that relax TM are promising for future glaucoma treatment strategies.