Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Management of peptic ulcers: emerging issues.

J W Freston1

  • 1Office of Clinical Research, University of Connecticut Health Center, Farmington, CT 06030, USA.

World Journal of Surgery
|February 5, 2000
PubMed
Summary

Most peptic ulcers stem from Helicobacter pylori infection, diagnosed via urea breath tests. Treatment involves eradicating H. pylori, though non-H. pylori ulcers present challenges.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes of gastric histology in patients with erosive oesophagitis receiving long-term lansoprazole maintenance therapy.

Alimentary pharmacology & therapeutics·2010
Same author

The clinical safety of long-term lansoprazole for the maintenance of healed erosive oesophagitis.

Alimentary pharmacology & therapeutics·2009
Same author

Rating the severity of the medical consequences of drug-induced liver injury.

Regulatory toxicology and pharmacology : RTP·2005
Same author

A novel option in proton pump inhibitor dosing: lansoprazole orally disintegrating tablet dispersed in water and administered via nasogastric tube.

Alimentary pharmacology & therapeutics·2004
Same author

Evaluation of the pharmacokinetics and pharmacodynamics of intravenous lansoprazole.

Alimentary pharmacology & therapeutics·2004
Same author

Review article: approaches to the long-term management of adults with GERD-proton pump inhibitor therapy, laparoscopic fundoplication or endoscopic therapy?

Alimentary pharmacology & therapeutics·2004

Area of Science:

  • Gastroenterology
  • Microbiology

Background:

  • Peptic ulcers are frequently caused by Helicobacter pylori infection.
  • Accurate diagnosis and effective eradication are crucial for managing peptic ulcer disease.
  • Non-H. pylori ulcers and their management remain a significant clinical challenge.

Purpose of the Study:

  • To review the diagnosis and treatment of peptic ulcers, focusing on Helicobacter pylori infection.
  • To discuss the role of various diagnostic tests and eradication regimens.
  • To explore the relationship between H. pylori, NSAIDs, and peptic ulcer development.

Main Methods:

  • Review of diagnostic methods including urea breath tests and serologic testing.
  • Discussion of current H. pylori eradication therapies.
  • Analysis of evidence regarding H. pylori's interaction with NSAIDs and its effect on ulcer development.

Main Results:

  • The radiolabeled carbon urea breath test is the preferred method for diagnosing H. pylori infection and confirming eradication.
  • Effective eradication regimens include proton pump inhibitors combined with clarithromycin/amoxicillin or bismuth/metronidazole/tetracycline.
  • Conflicting evidence exists regarding H. pylori's role in NSAID-related ulcers, and non-H. pylori ulcers are often refractory to treatment.

Conclusions:

  • H. pylori eradication is the cornerstone of modern peptic ulcer treatment for infected individuals.
  • While effective treatments exist, non-H. pylori ulcers require further investigation and management strategies.
  • Potential links between H. pylori eradication and erosive esophagitis warrant further research.

Related Experiment Videos