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Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
Published on: February 26, 2019
A study on the influence of basic nutrients on glucose and glycine transport in the small intestine
B Popov1, R Vasileva, V Goranova
1Department of Hygiene, Ecology and Professional Diseases, Medical Academy, Sofia, Bulgaria.
Introduction:
The present study addresses the questions of the onset of adaptation of the small intestine transport functions to different nutritional effects and of the extent to which the detected changes could be interpreted as adaptive.
Material And Methods:
Two independent experiments with male white rats as experimental animals were carried out. In the first experiment three groups of animals were subjected to a single administration of respectively unadulterated protein, carbohydrates and fatty food and were examined 4 hours after end of feeding. In the second experiment the same diets were applied in the course of 10 days. In both experiments the glucose and glycine absorption was studied by means of the method of accumulating preparation from the mucosa of small intestine "in vitro".
Results:
We found that rapid readjustment responses to the nutritional effects of basic nutrients could be detected as early as 4 hours after the food intake only in the carbohydrate transport systems. In the case of amino acids adequate changes in their transport systems were registered as late as 10 days after their reception.
Conclusions:
The mechanisms of the rapid adaptive responses are probably not associated with any quantitative changes in the enzyme and transport capacity of the small intestine but amount to its efficient readjustment in accordance with the specific nutritional effect.
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