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Prostaglandin E2 in preinduction cervical ripening in postdate pregnancy
N Milchev1, B Pehlivanov, V Paskaleva
1Department of Obstetrics and Gynecology, Higher Medical Institute, Plovdiv, Bulgaria.
Folia Medica
|February 5, 2000
Summary
Prostaglandin E2 effectively ripens the cervix before labor induction in postdate pregnancies. Both Prepidil-gel and Prostin E2 showed similar efficacy and safety, though Prostin E2 was easier to administer.
Area of Science:
- Obstetrics and Gynecology
- Reproductive Medicine
Background:
- Unripe cervix is a significant factor in labor induction failure.
- It is linked to increased operative delivery, adverse fetal outcomes, and maternal morbidity.
Purpose of the Study:
- To evaluate the efficacy of prostaglandin E2 (PGE2) for preinduction cervical ripening in postdate pregnancies.
- To compare two PGE2 preparations: Prepidil-gel and Prostin E2.
Main Methods:
- A study involving 42 women with postdate pregnancies and unripe cervices requiring labor induction.
- Participants were divided into two groups: one receiving Prepidil-gel and the other Prostin E2.
Main Results:
- Prostaglandin E2 demonstrated a favorable ripening effect in 85.7% of women.
- No significant differences were observed in efficacy, safety, or pregnancy outcomes between the two PGE2 preparations.
Conclusions:
- Prostaglandin E2 is an effective method for preinduction cervical ripening in postdated pregnancies.
- Prostin E2 is preferred due to its ease of application, despite similar efficacy to Prepidil-gel.