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Synthesis and BZR affinity of pyrazolo[1,5-a]pyrimidine derivatives. Part 1: study of the structural features for BZR
S Selleri1, F Bruni, C Costagli
1Department of Pharmaceutical Sciences, University of Firenze, Florence, Italy. sell@farmfi.scifarm.unifi.it
Bioorganic & Medicinal Chemistry
|February 5, 2000
Abstract:
Examination of the pharmacophoric points of the pyrazolo[1,5-a]pyrimidine derivatives, ligands for BZR, previously published led us to the design of a novel class of 3,6-diaryl-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-7-ones and to determine the groups involved in the BZR recognition.